Comments on “Significance of candidate cancer genes as assessed by the CaMP score” by Parmigiani et al
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چکیده
Identifying genes that are involved in the development of cancer has been a very important research goal. One approach tries to identify genes in tumors that have an increased mutation rate. [Sjöblom et al., 2006] sequenced 13,023 CCDS genes in breast and colorectal cancer tumors. CCDS genes are protein encoding genes and represent the most highly curated gene set currently available. The data collection phase consisted of two main parts in which genes that were deemed not to have an increased mutation rate were eliminated. In particular, these two parts were:
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